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ACCUPRIL (QUINAPRIL HYDROCHLORIDE): DOSAGE AND ADMINISTRATION
The recommended initial dosage of Accupril (Quinapril HCl) tablets in patients not on diuretics is 10 or 20 mg once daily. Dosage should be adjusted according to blood pressure response measured at peak (2.6 hours after dosing) and trough (predosing). Generally, dosage adjustments should be made at intervals of at least 2 weeks. Most patients have required dosages of 20, 40, or 80 mg/day, given as a single dose or in two equally divided doses. In some patients treated once daily, the antihypertensive effect may diminish toward the end of the dosing interval. In such patients an increase in dosage or twice daily administration may be warranted. In general, doses of 40.80 mg and divided doses give a somewhat greater effect at the end of the dosing interval.
If blood pressure is not adequately controlled with Accupril (Quinapril Hydrochloride) monotherapy, a diuretic may be added. In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally can occur following the initial dose of Accupril (Quinapril Hydrochloride) tablets. To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued 2 to 3 days prior to beginning therapy with this medication. Then, if blood pressure is not controlled with Quinapril (Accupril) alone, diuretic therapy should be resumed.
If the diuretic cannot be discontinued, an initial dose of 5 mg Quinapril (Accupril) tablets should be used with careful medical supervision for several hours and until blood pressure has stabilized.
The dosage should subsequently be titrated (as described above) to the optimal response.
Kinetic data indicate that the apparent elimination half-life of quinaprilat increases as creatinine clearance decreases. Recommended starting doses, based on clinical and pharmacokinetic data from patients with renal impairment, are as follows:
Maximum Recommended Initial Dose: 10 mg Creatinine Clearance > 60 mL/min); 5 mg Creatinine Clearance > 30-60 mL/min); 2.5 mg Creatinine Clearance > 10-30 mL/min);
Patients should subsequently have their dosage titrated (as described above) to the optimal response.
The recommended initial dosage of Quinapril HCl (Accupril) in elderly patients ( >= 65 years) is 10 mg given once daily followed by titration (as described above) to the optimal response.
Quinapril HCl (Accupril) tablets is indicated as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis. The recommended starting dose is 5 mg twice daily. This dose may improve symptoms of heart failure, but increases in exercise duration have generally required higher doses. Therefore, if the initial dosage of Quinapril Hydrochloride (Accupril) is well tolerated, patients should then be titrated at weekly intervals until an effective dose, usually 20 to 40 mg daily given in two equally divided doses, is reached or undesirable hypotension, orthostatis, or azotemia prohibit reaching this dose.
Following the initial dose of Quinapril Hydrochloride (Accupril) tablets, the patient should be observed under medical supervision for at least two hours for the presence of hypotension or orthostatis and, if present, until blood pressure stabilizes. The appearance of hypotension, orthostatis, or azotemia early in dose titration should not preclude further careful dose titration. Consideration should be given to reducing the dose of concomitant diuretics.
Dose adjustments in patients with heart failure and renal impairment or hyponatremia
Pharmacokinetic data indicate that quinapril elimination is dependent on level of renal function. In patients with heart failure and renal impairment, the recommended initial dose of Accupril (Quinapril) is 5 mg in patients with a creatinine clearance above 30 mL/min and 2.5 mg in patients with a creatinine clearance of 10 to 30 mL/min. There is insufficient data for dosage recommendation in patients with a creatinine clearance less than 10 mL/min.
If the initial dose is well tolerated, Accupril (Quinapril) tablets may be administered the following day as a twice daily regimen. In the absence of excessive hypotension or significant deterioration of renal function, the dose may be increased at weekly intervals based on clinical and hemodynamic response.
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