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ACCUPRIL (QUINAPRIL HYDROCHLORIDE): PRESCRIBING INFORMATION
Accupril (Quinapril Hydrochloride) is the hydrochloride salt of quinapril, the ethyl ester of a non-sulfhydryl, angiotensin-converting enzyme (ACE) inhibitor, quinaprilat.
Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5 x HCl.
Quinapril Hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents.
Accupril tablets contain 5 mg, 10 mg, 20 mg, or 40 mg of quinapril for oral administration.
Each tablet also contains crospovidone, candelilla wax, gelatin, magnesium carbonate, lactose, magnesium stearate, synthetic red iron oxide, and titanium dioxide.
INDICATIONS AND USAGE
Accupril indications and usage
Accupril (Quinapril HCl) is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.
DOSAGE AND ADMINISTRATION
Accupril dosage and administration
Accupril clinical pharmacology
Accupril drug interactions
Accupril special populations
Accupril adverse reactions
STORAGE / HOW SUPPLIED
Accupril (Quinapril Hydrochloride) tablets are supplied in bottles and blisters as follows:
5 mg tablets: brown, film-coated, elliptical scored tablets, coded "PD 527" on one side and "5" on the other
10 mg tablets: brown, film-coated, triangular tablets, coded "PD 530" on one side and "10" on the other.
20 mg tablets: brown, film-coated, round tablets, coded "PD 532" on one side and "20" on the other.
40 mg tablets: brown, film-coated, elliptical tablets, coded "PD 535" on one side and "40" on the other.
Dispense in well-closed containers as defined in the USP.
Store Quinapril (Accupril) tablets at controlled room temperature 15° - 30° (59° - 86°).
Protect from light.
Manufactured and distributed by Pfizer, Parke-Davis pharmaceutical companies and their divisions.
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